High drug-loading nanomedicines: progress, current status, and prospects

S Shen, Y Wu, Y Liu, D Wu - International journal of nanomedicine, 2017 - Taylor & Francis
Drug molecules transformed into nanoparticles or endowed with nanostructures with or
without the aid of carrier materials are referred to as “nanomedicines” and can overcome …

Designing smart polymer conjugates for controlled release of payloads

F Seidi, R Jenjob, D Crespy - Chemical reviews, 2018 - ACS Publications
Incorporating labile bonds inside polymer backbone and side chains yields interesting
polymer materials that are responsive to change of environmental stimuli. Drugs can be …

Self-assembled nanostructures from amphiphilic block copolymers prepared via ring-opening metathesis polymerization (ROMP)

S Varlas, SB Lawrenson, LA Arkinstall… - Progress in Polymer …, 2020 - Elsevier
The development of controlled/living polymerization methodologies has underpinned a
rapid expanse in our understanding of amphiphilic block copolymer self-assembly. In …

Cylindrical polymer brushes–Anisotropic building blocks, unimolecular templates and particulate nanocarriers

M Müllner, AHE Müller - Polymer, 2016 - Elsevier
This article presents an overview of the latest key developments and research activities in
the area of cylindrical polymer brushes (CPBs), also known as 'molecular bottlebrushes' …

Polymer-drug conjugates: Design principles, emerging synthetic strategies and clinical overview

A Javia, J Vanza, D Bardoliwala, S Ghosh… - International Journal of …, 2022 - Elsevier
Adagen, an enzyme replacement treatment for adenosine deaminase deficiency, was the
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …

Recent advances in formulation and application of molecular polymer brushes in biomedicine: Therapeutic, diagnostic, and theranostics capabilities

F Adeli, F Abbasi, P Ghandforoushan, HE Külahlı… - Nano Today, 2023 - Elsevier
The applications of nanotechnology in medical sciences, especially in drug and gene
delivery, has experienced unprecedented growth in recent years. The integration of …

Grubbs' and Schrock's catalysts, ring opening metathesis polymerization and molecular brushes—synthesis, characterization, properties and applications

I Choinopoulos - Polymers, 2019 - mdpi.com
In this review, molecular brushes and other macromolecular architectures bearing a
bottlebrush segment where the main chain is synthesized by ring opening metathesis …

Molecular polymer brushes in nanomedicine

M Müllner - Macromolecular Chemistry and Physics, 2016 - Wiley Online Library
Nanomedicine is one of the fastest growing areas of nanotechnology. The control over
nanoparticle design and the ability to tailor nanoparticle performance to fit exacting …

Engineering of molecular geometry in bottlebrush polymers

DJ Walsh, S Dutta, CE Sing, D Guironnet - Macromolecules, 2019 - ACS Publications
Bottlebrush polymers are large cylindrical macromolecules, where a molecular “width”
emerges from a large number of side chains densely attached to a central backbone. The …

Near-infrared fluorescent micelles from poly (norbornene) brush triblock copolymers for nanotheranostics

CB Braga, RA Pilli, C Ornelas, M Weck - Biomacromolecules, 2021 - ACS Publications
This contribution describes the design and synthesis of multifunctional micelles based on
amphiphilic brush block copolymers (BBCPs) for imaging and selective drug delivery of …