Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

CDC45-MCM2-7-GINS (CMG) helicase assembly is the central event in eukaryotic
replication initiation. In yeast, a multi-subunit “pre-loading complex”(pre-LC) accompanies …

Malformations of cerebral cortical development include a wide range of developmental
disorders that are common causes of neurodevelopmental delay and epilepsy. In addition …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …

The recognition of distinctly modified histones by specialized 'effector'proteins constitutes a
key mechanism for transducing molecular events at chromatin to biological outcomes …

BACKGROUND Cellular life depends on the ability of organisms to accurately duplicate and
transmit genetic information between generations. In bacteria, archaea, and eukaryotes, this …

DNA methylation and Polycomb are key factors in the establishment of vertebrate cellular
identity and fate. Here we report de novo missense mutations in DNMT3A, which encodes …

Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of
defense have evolved to reduce the accumulation of DNA damage, including reducing …