Mechanisms regulating resistance to inhibitors of topoisomerase II
RN Ganapathi, MK Ganapathi - Frontiers in pharmacology, 2013 - frontiersin.org
Inhibitors of topoisomerase II (topo II) are clinically effective in the management of
hematological malignancies and solid tumors. The efficacy of anti-tumor drugs targeting topo …
hematological malignancies and solid tumors. The efficacy of anti-tumor drugs targeting topo …
Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death
AK Larsen, A Skladanowski - Biochimica et Biophysica Acta (BBA)-Gene …, 1998 - Elsevier
DNA topoisomerase inhibitors are important antineoplastic agents used in the treatment of
both leukemias and solid tumors, such as breast, lung and colon cancers. Their clinical …
both leukemias and solid tumors, such as breast, lung and colon cancers. Their clinical …
Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
R Strick, PL Strissel, S Borgers… - Proceedings of the …, 2000 - National Acad Sciences
Chromosomal translocations involving the MLL gene occur in about 80% of infant leukemia.
In the search for possible agents inducing infant leukemia, we identified bioflavonoids …
In the search for possible agents inducing infant leukemia, we identified bioflavonoids …
Etoposide targets topoisomerase IIα and IIβ in leukemic cells: Isoform-specific cleavable complexes visualized and quantifiedin situ by a novel immunofluorescence …
E Willmore, AJ Frank, K Padget, MJ Tilby… - Molecular pharmacology, 1998 - ASPET
We have shown that both DNA topoisomerase (topo) IIα and β are in vivo targets for
etoposide using a new assay which directly measures topo IIα and β cleavable complexes in …
etoposide using a new assay which directly measures topo IIα and β cleavable complexes in …
Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs
CA Mann, JJ Carvajal Moreno, Y Lu… - Antimicrobial agents …, 2023 - Am Soc Microbiol
Antimicrobial resistance has made a sizeable impact on public health and continues to
threaten the effectiveness of antibacterial therapies. Novel bacterial topoisomerase …
threaten the effectiveness of antibacterial therapies. Novel bacterial topoisomerase …
Mechanisms of action and reduced cardiotoxicity of pixantrone; a topoisomerase II targeting agent with cellular selectivity for the topoisomerase IIα isoform
BB Hasinoff, X Wu, D Patel, R Kanagasabai… - … of Pharmacology and …, 2016 - ASPET
Pixantrone is a new noncardiotoxic aza-anthracenedione anticancer drug structurally
related to anthracyclines and anthracenediones, such as doxorubicin and mitoxantrone …
related to anthracyclines and anthracenediones, such as doxorubicin and mitoxantrone …
DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis
PL Strissel, R Strick, RJ Tomek, BA Roe… - Human molecular …, 2000 - academic.oup.com
The human AF9 gene at 9p22 is one of the most common fusion partner genes with the MLL
gene at 11q23, resulting in the t (9; 11)(p22; q23). The MLL–AF9 fusion gene is associated …
gene at 11q23, resulting in the t (9; 11)(p22; q23). The MLL–AF9 fusion gene is associated …
Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu (II)
BB Hasinoff, X Wu, AA Yadav, D Patel, H Zhang… - Biochemical …, 2015 - Elsevier
The potent anticancer drug elesclomol, which forms an extremely strong complex with
copper, is currently undergoing clinical trials. However, its mechanism of action is not well …
copper, is currently undergoing clinical trials. However, its mechanism of action is not well …
Intronic polyadenylation in acquired cancer drug resistance circumvented by utilizing CRISPR/Cas9 with homology-directed repair: The tale of human DNA …
TS Elton, VA Hernandez, J Carvajal-Moreno, X Wang… - Cancers, 2022 - mdpi.com
Simple Summary DNA topoisomerase IIα (170 kDa, TOP2α/170) resolves nucleic acid
topological entanglements by generating transient double-strand DNA breaks. TOP2α …
topological entanglements by generating transient double-strand DNA breaks. TOP2α …
1, 3-Dioxane-linked bacterial topoisomerase inhibitors with enhanced antibacterial activity and reduced hERG inhibition
L Li, AA Okumu, S Nolan, A English… - ACS infectious …, 2019 - ACS Publications
The development of new therapies to treat methicillin-resistant Staphylococcus aureus
(MRSA) is needed to counteract the significant threat that MRSA presents to human health …
(MRSA) is needed to counteract the significant threat that MRSA presents to human health …