Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

The key hallmark of stem cells is their ability to self-renew while keeping a differentiation
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …

CD133 marks self-renewing cancer stem cells (CSCs) in a variety of solid tumors, and
CD133+ tumor-initiating cells are known markers of chemo-and radio-resistance in multiple …

Adult kidney organoids have been described as strictly tubular epithelia and termed
tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that …

Whether kidney proximal tubule harbors a scattered population of epithelial stem cells is a
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …

STUDY QUESTION Could cell therapy using autologous peripheral blood CD133+ bone
marrow-derived stem cells (BMDSCs) offer a safe and efficient therapeutic approach for …

The acutely injured mammalian kidney mounts a cellular and molecular response to repair
itself. However, in patchy regions such intrinsic processes are impaired and dysregulated …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …