An update on larynx cancer

CE Steuer, M El‐Deiry, JR Parks… - CA: a cancer journal …, 2017 - Wiley Online Library
Answer questions and earn CME/CNE Laryngeal cancer remains one of the most common
tumors of the respiratory tract. Fortunately, significant advancements have been made over …

HER3 in cancer: from the bench to the bedside

L Gandullo-Sánchez, A Ocaña, A Pandiella - Journal of Experimental & …, 2022 - Springer
The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is
expressed in several types of tumors. That fact, together with the role of HER3 in promoting …

Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer

HK Byeon, M Ku, J Yang - Experimental & molecular medicine, 2019 - nature.com
Epidermal growth factor receptor (EGFR) overexpression is common in head and neck
squamous cell carcinoma. Targeted therapy specifically directed towards EGFR has been …

Carcinogenic epithelial-mesenchymal transition initiated by oral cancer exosomes is inhibited by anti-EGFR antibody cetuximab

T Fujiwara, T Eguchi, C Sogawa, K Ono, J Murakami… - Oral oncology, 2018 - Elsevier
Overexpression and increased signaling from the epidermal growth factor receptor (EGFR)
often changes oral squamous cell carcinoma (OSCC) and thus EGFR is frequently targeted …

Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

Z Wang, Y Goto, MM Allevato, VH Wu… - Nature …, 2021 - nature.com
Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous
cell carcinoma (HNSCC) treatment, but< 20% of patients achieve durable responses …

NIR-II emissive dye based polymer nanoparticle targeting EGFR for oral cancer theranostics

M Ling, R Sun, G Li, MZ Syeda, W Ma, Z Mai, L Shao… - Nano Research, 2022 - Springer
Oral cancer is a common malignant tumor of the head and neck, and surgery combined with
radiotherapy and chemotherapy is the primary treatment modality. However, a positive …

BET inhibition overcomes receptor tyrosine kinase–mediated cetuximab resistance in HNSCC

B Leonard, TM Brand, RA O'Keefe, ED Lee, Y Zeng… - Cancer research, 2018 - AACR
Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell
carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and …

Combination therapy as a promising way to fight oral cancer

JPN Silva, B Pinto, L Monteiro, PMA Silva, H Bousbaa - Pharmaceutics, 2023 - mdpi.com
Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis
and high mortality rates. Conventional treatment strategies, such as surgery, chemotherapy …

Precision medicine approaches to overcome resistance to therapy in head and neck cancers

S Ortiz-Cuaran, J Bouaoud, A Karabajakian… - Frontiers in …, 2021 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most incident cancer
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …

New clinical trial design in precision medicine: discovery, development and direction

XP Duan, BD Qin, XD Jiao, K Liu, Z Wang… - Signal Transduction and …, 2024 - nature.com
In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …