Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis

W Zhang, R Gao, X Rong, S Zhu, Y Cui… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone
microarchitecture, with an increased risk of fractures. Classical theories hold that …

Osteometabolism: metabolic alterations in bone pathologies

RK Srivastava, L Sapra, PK Mishra - Cells, 2022 - mdpi.com
Renewing interest in the study of intermediate metabolism and cellular bioenergetics is
brought on by the global increase in the prevalence of metabolic illnesses. Understanding of …

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review

J Riegger, A Schoppa, L Ruths… - Cellular & molecular …, 2023 - Springer
During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

Integrated bioinformatic analysis of the shared molecular mechanisms between osteoporosis and atherosclerosis

L Mo, C Ma, Z Wang, J Li, W He, W Niu… - Frontiers in …, 2022 - frontiersin.org
Background Osteoporosis and atherosclerosis are common in the elderly population,
conferring a heavy worldwide burden. Evidence links osteoporosis and atherosclerosis but …

The inflammatory contribution of B-lymphocytes and neutrophils in progression to osteoporosis

D Frase, C Lee, C Nachiappan, R Gupta, A Akkouch - Cells, 2023 - mdpi.com
Osteoporosis is a bone disease characterized by structural deterioration and low bone
mass, leading to fractures and significant health complications. In this review, we summarize …

Understanding the consequences of fatty bone and fatty muscle: how the osteosarcopenic adiposity phenotype uncovers the deterioration of body composition

K Hu, E Deya Edelen, W Zhuo, A Khan, J Orbegoso… - Metabolites, 2023 - mdpi.com
Adiposity is central to aging and several chronic diseases. Adiposity encompasses not just
the excess adipose tissue but also body fat redistribution, fat infiltration, hypertrophy of …

Unravelling the immunobiology of innate lymphoid cells (ILCs): Implications in health and disease

RK Srivastava, L Sapra, A Bhardwaj, PK Mishra… - Cytokine & Growth …, 2023 - Elsevier
Innate lymphoid cells (ILCs), a growing class of immune cells, imitate the appearance and
abilities of T cells. However, unlike T cells, ILCs lack acquired antigen receptors, and they …

Exercise and exercise mimetics for the treatment of musculoskeletal disorders

AS Cento, M Leigheb, G Caretti, F Penna - Current osteoporosis reports, 2022 - Springer
Abstract Purpose of Review The incidence of musculoskeletal disorders affecting bones,
joints, and muscles is dramatically increasing in parallel with the increased longevity of the …

Fine‐tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis

A Anwar, L Sapra, N Gupta, RP Ojha… - Journal of cellular …, 2023 - Wiley Online Library
Osteoclasts, the bone‐resorbing cells, are essential for the bone remodeling process and
are involved in the pathophysiology of several bone‐related diseases. The extensive corpus …

Immunology of osteoporosis: relevance of inflammatory targets for the development of novel interventions

SS Ahmad, F Ahmed, R Ali, MM Ghoneim… - …, 2022 - Taylor & Francis
Osteoporosis is recognized as low bone mass and deteriorated bone microarchitecture. It is
the leading cause of fractures and consequent morbidity globally. The established …