High‐throughput screening and small animal models, where are we?

J Giacomotto, L Ségalat - British journal of pharmacology, 2010 - Wiley Online Library
Current high‐throughput screening methods for drug discovery rely on the existence of
targets. Moreover, most of the hits generated during screenings turn out to be invalid after …

Zebrafish as a model organism for nutrition and growth: towards comparative studies of nutritional genomics applied to aquacultured fishes

PE Ulloa, P Iturra, R Neira, C Araneda - Reviews in Fish Biology and …, 2011 - Springer
Zebrafish (Danio rerio) is a common research model in fish studies of toxicology,
developmental biology, neurobiology and molecular genetics; it has been proposed as a …

Associative learning in zebrafish (Danio rerio) in the plus maze

M Sison, R Gerlai - Behavioural brain research, 2010 - Elsevier
Zebrafish has been gaining increasing amount of interest in behavioral neuroscience as this
species may represent a good compromise between system complexity and practical …

Zebrafish: a multifaceted tool for chemical biologists

S Basu, C Sachidanandan - Chemical reviews, 2013 - ACS Publications
In 1868, Friedrich Miescher completed his medical training and joined the physiological
chemistry laboratory of Felix Hoppe-Seyler to study the chemical composition of biological …

[图书][B] Handbook of Laboratory Animal Science: Animal Models, Volume II

J Hau, SJ Schapiro, GL Van Hoosier Jr - 2002 - taylorfrancis.com
The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

Zebrafish: A premier vertebrate model for biomedical research in indian scenario

S Sarasamma, MM Varikkodan, ST Liang, YC Lin… - Zebrafish, 2017 - liebertpub.com
The zebrafish (Danio rerio) is a versatile model organism that has been used in biomedical
research for several decades to study a wide range of biological phenomena. There are …

Chromosome evolution in African cichlid fish: contributions from the physical mapping of repeated DNAs

IA Ferreira, AB Poletto, TD Kocher… - … and genome research, 2010 - karger.com
Cichlid fishes have been the subject of increasing scientific interest because of their rapid
adaptive radiation that has led to extensive ecological diversity and because of their …

Anti-cancer drug discovery: Update and comparisons in yeast, Drosophila, and zebrafish

G Gao, L Chen, C Huang - Current molecular pharmacology, 2014 - ingentaconnect.com
Discovery of novel cancer chemotherapeutics focuses on screening and identifying
compounds that can target 'cancer-specific'biological processes while causing minimal …

Short stories on zebrafish long noncoding RNAs

S Haque, K Kaushik, VE Leonard, S Kapoor, A Sivadas… - Zebrafish, 2014 - liebertpub.com
The recent re-annotation of the transcriptome of human and other model organisms, using
next-generation sequencing approaches, has unravelled a hitherto unknown repertoire of …

Comparative cytogenetics of cichlid fishes through genomic in-situ hybridization (GISH) with emphasis on Oreochromis niloticus

G Targino Valente, C Henrique Schneider… - Chromosome …, 2009 - Springer
Cichlidae is the most species-rich freshwater family of Perciformes and has attracted the
attention of aquarium hobbyists, aquaculturists, and sport fisherman. Oreochromis niloticus …