Aim: The etiology of hypertension is various and complex, involving both genetic and
behavioral factors. The relationship between psychosocial stress and hypertension has …

Essential hypertension, a rise in blood pressure of undetermined cause, includes 90% of all
hypertensive cases and is a highly important public health challenge that remains, however …

Stress-and anxiety-related disorders are on the rise in both military and general populations.
Over the next decade, it is predicted that treatment of these conditions, in particular …

Present in more than one billion adults, hypertension is the most significant modifiable risk
factor for mortality resulting from cardiovascular disease. Although its pathogenesis is not yet …

Over-activation of the brain renin-angiotensin system (RAS) has been implicated in the
etiology of anxiety disorders. Angiotensin converting enzyme 2 (ACE2) inhibits RAS activity …

Background The current effective treatment options for posttraumatic stress disorder (PTSD)
are limited, and therefore the need to explore new treatment strategies is critical …

The medial prefrontal cortex is critical for contextual appraisal, executive function, and goal-
directed behavior. Additionally, the infralimbic (IL) subregion of the prefrontal cortex has …

Stress elicits neuroendocrine, autonomic, and behavioral responses that mitigate
homeostatic imbalance and ensure survival. However, chronic engagement of such …

Angiotensin-II acts at its type-1 receptor (AT1R) in the brain to regulate body fluid
homeostasis, sympathetic outflow and blood pressure. However, the role of the angiotensin …

Abstract Brain angiotensin-II (Ang-II) type-1 receptors (AT1Rs), which exert profound effects
on normal cardiovascular, fluid, and metabolic homeostasis, are overactivated in and …