Exosomes‐loaded Electroconductive hydrogel synergistically promotes tissue repair after spinal cord injury via Immunoregulation and enhancement of myelinated …

L Fan, C Liu, X Chen, L Zheng, Y Zou, H Wen… - Advanced …, 2022 - Wiley Online Library
Electroconductive hydrogels are very attractive candidates for accelerated spinal cord injury
(SCI) repair because they match the electrical and mechanical properties of neural tissue …

It's all in the delivery: designing hydrogels for cell and non-viral gene therapies

RL Youngblood, NF Truong, T Segura, LD Shea - Molecular Therapy, 2018 - cell.com
Hydrogels provide a regenerative medicine platform with their ability to create an
environment that supports transplanted or endogenous infiltrating cells and enables these …

A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury

H Shen, B Xu, C Yang, W Xue, Z You, X Wu, D Ma… - Biomaterials, 2022 - Elsevier
Spinal cord injury (SCI) creates an inflammatory microenvironment characterized by
damage-associated molecular patterns (DAMPs) and immune cell activation that exacerbate …

The immunological roles of olfactory ensheathing cells in the treatment of spinal cord injury

Y Jiang, J Guo, X Tang, X Wang, D Hao… - Frontiers in …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a devastating type of neurological disorder of the central nervous
system (CNS) with high mortality and disability. The pathological processes of SCI can …

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after …

J Ren, B Zhu, G Gu, W Zhang, J Li, H Wang… - Cell death & …, 2023 - nature.com
Macrophage/microglia polarization acts as an important part in regulating inflammatory
responses in spinal cord injury (SCI). However, the regulation of inflammation of Schwann …

Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury

J Park, Y Zhang, E Saito… - Proceedings of the …, 2019 - National Acad Sciences
Traumatic primary spinal cord injury (SCI) results in paralysis below the level of injury and is
associated with infiltration of hematogenous innate immune cells into the injured cord …

Neutrophil decoys with anti‐inflammatory and anti‐oxidative properties reduce secondary spinal cord injury and improve neurological functional recovery

Y Bi, W Duan, J Chen, T You, S Li… - Advanced Functional …, 2021 - Wiley Online Library
Following spinal cord injury (SCI), immune cell infiltration creates an inflammatory and
oxidative microenvironment (known as the secondary injury), which causes neuron death …

Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice

A Mastinu, SA Bonini, M Premoli, G Maccarinelli… - Molecules, 2021 - mdpi.com
Gynostemma pentaphyllum (var. Ginpent)(GP) is a variety of Cucurbit with anti-inflammatory
and antioxidant effects in patients. In this manuscript, the main components present in the …

Reducing inflammation through delivery of lentivirus encoding for anti-inflammatory cytokines attenuates neuropathic pain after spinal cord injury

J Park, JT Decker, DR Smith, BJ Cummings… - Journal of controlled …, 2018 - Elsevier
Recently, many clinical trials have challenged the efficacy of current therapeutics for
neuropathic pain after spinal cord injury (SCI) due to their life-threatening side-effects …

Neuroprotective effects of interleukin 10 in spinal cord injury

J Li, P Wang, T Zhou, W Jiang, H Wu… - Frontiers in Molecular …, 2023 - frontiersin.org
Spinal cord injury (SCI) starts with a mechanical and/or bio-chemical insult, followed by a
secondary phase, leading progressively to severe collapse of the nerve tissue. Compared to …