Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

Atomic force microscopy (AFM) is an easy‐to‐use, powerful, high‐resolution microscope that
allows the user to image any surface and under any aqueous condition. AFM has been used …

According to the 'amyloid cascade hypothesis of Alzheimer's disease'first proposed about 16
years ago, the accumulation of Aβ peptides in the human central nervous system (CNS) is …

The presence of amyloid plaques in the brain is a typical characteristic of Alzheimer's
disease (AD). Amyloid plaques are formed from the deposits of aggregated amyloid β …

The field of Alzheimer's disease (AD) research has grown exponentially over the past few
decades, especially since the isolation and identification of amyloid-β from postmortem …

Background: K-Ras4B modulates downstream signaling at different lipid microdomains.
Results: K-Ras4B farnesyl group spontaneously inserts into the disordered lipid …

Amyloid-β (Aβ) oligomers destabilize cellular ionic homeostasis, mediating Alzheimer's
disease (AD). It is still unclear whether the mechanism (i) is mediated by cell surface …

Amyloid-beta peptides (Aβ), implicated in Alzheimer's disease (AD), interact with the cellular
membrane and induce amyloid toxicity. The composition of cellular membranes changes in …

Trehalose is a natural disaccharide with a remarkable ability to stabilize biomolecules. In
recent years, trehalose has received growing attention as a neuroprotective molecule and …