Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Our skin is the largest organ of the body, serving as an important barrier against the harsh
extrinsic environment. Alongside preventing desiccation, chemical damage and …

Cultured cell lines are the workhorse of cancer research, but the extent to which they
recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here …

Cellular senescence has been shown to contribute to skin ageing. However, the role of
melanocytes in the process is understudied. Our data show that melanocytes are the only …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …

Genome-scale models of metabolism can illuminate the molecular basis of cell phenotypes.
Since some enzymes are only active in specific cell types, several algorithms use omics data …

Cellular senescence is a stress response program characterized by a robust cell cycle arrest
and the induction of a proinflammatory senescence-associated secretory phenotype (SASP) …

The canonical Wnt pathway is one of the key cellular signaling cascades that regulates, via
the transcriptional co-activator β-catenin, numerous embryogenic developmental processes …

Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for
proper regeneration. Altering balanced niche signalling can lead to regenerative disorders …

Oncogene-induced senescence (OIS) is a stable cell cycle arrest that occurs in normal cells
upon oncogene activation. Cells undergoing OIS express a wide variety of secreted factors …