[HTML][HTML] Hypoalbuminemia as surrogate and culprit of infections

CJ Wiedermann - International journal of molecular sciences, 2021 - mdpi.com
Hypoalbuminemia is associated with the acquisition and severity of infectious diseases, and
intact innate and adaptive immune responses depend on albumin. Albumin oxidation and …

[HTML][HTML] Serum albumin: a multifaced enzyme

G De Simone, A di Masi, P Ascenzi - International Journal of Molecular …, 2021 - mdpi.com
Human serum albumin (HSA) is the most abundant protein in plasma, contributing actively to
oncotic pressure maintenance and fluid distribution between body compartments. HSA acts …

ACG clinical guidelines: prevention, diagnosis, and treatment of Clostridioides difficile infections

CR Kelly, M Fischer, JR Allegretti… - Official journal of the …, 2021 - journals.lww.com
Clostridioides difficile infection occurs when the bacterium produces toxin that causes
diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to …

[HTML][HTML] 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients

M Sartelli, S Di Bella, LV McFarland, S Khanna… - World Journal of …, 2019 - Springer
In the last three decades, Clostridium difficile infection (CDI) has increased in incidence and
severity in many countries worldwide. The increase in CDI incidence has been particularly …

[HTML][HTML] Organoids as host models for infection biology–a review of methods

C Aguilar, M Alves da Silva, M Saraiva… - … & Molecular Medicine, 2021 - nature.com
Infectious diseases are a major threat worldwide. With the alarming rise of antimicrobial
resistance and emergence of new potential pathogens, a better understanding of the …

[HTML][HTML] Drug inhibition of SARS-CoV-2 replication in human pluripotent stem cell–derived intestinal organoids

J Krüger, R Groß, C Conzelmann, JA Müller… - Cellular and Molecular …, 2021 - Elsevier
Background and aims The COVID-19 pandemic has spread worldwide and poses a severe
health risk. While most patients present mild symptoms, descending pneumonia can lead to …

Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …

The gut bacterial community potentiates Clostridioides difficile infection severity

NA Lesniak, AM Schubert, KJ Flynn, JL Leslie, H Sinani… - MBio, 2022 - Am Soc Microbiol
The severity of Clostridioides difficile infections (CDI) has increased over the last few
decades. Patient age, white blood cell count, and creatinine levels as well as C. difficile …

Prediction of the interaction between HIV viruses and human serum albumin (HSA) molecules using an equilibrium dynamics simulation program for application in bio …

A Karimipour, A Karimipour, NA Jolfaei… - Journal of Molecular …, 2020 - Elsevier
Abstract Atomic interaction of Human Serum Albumin (HSA) protein and HIV virus is
important in medical sciences. In the present study, for the first time, Molecular Dynamics …

[PDF][PDF] Human peptide α‐defensin‐1 interferes with Clostridioides difficile toxins TcdA, TcdB, and CDT

S Fischer, AK Ückert, M Landenberger… - The FASEB …, 2020 - oparu.uni-ulm.de
The human pathogenic bacterium Clostridioides difficile produces two exotoxins TcdA and
TcdB, which inactivate Rho GTPases thereby causing C. difficile‐associated diseases …