Skeletal muscle energy metabolism during exercise
M Hargreaves, LL Spriet - Nature metabolism, 2020 - nature.com
The continual supply of ATP to the fundamental cellular processes that underpin skeletal
muscle contraction during exercise is essential for sports performance in events lasting …
muscle contraction during exercise is essential for sports performance in events lasting …
Metabolic and signaling roles of ketone bodies in health and disease
P Puchalska, PA Crawford - Annual review of nutrition, 2021 - annualreviews.org
Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …
Targeting mitochondria-inflammation circuit by β-hydroxybutyrate mitigates HFpEF
Y Deng, M Xie, Q Li, X Xu, W Ou, Y Zhang… - Circulation …, 2021 - Am Heart Assoc
Rationale: Over 50% of patients with heart failure have preserved ejection fraction (HFpEF),
rather than reduced ejection fraction. Complexity of its pathophysiology and the lack of …
rather than reduced ejection fraction. Complexity of its pathophysiology and the lack of …
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
F Karagiannis, K Peukert, L Surace, M Michla… - Nature, 2022 - nature.com
Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch
towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate …
towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate …
[HTML][HTML] SGLT2 inhibition mediates protection from diabetic kidney disease by promoting ketone body-induced mTORC1 inhibition
I Tomita, S Kume, S Sugahara, N Osawa, K Yamahara… - Cell metabolism, 2020 - cell.com
SGLT2 inhibitors offer strong renoprotection in subjects with diabetic kidney disease (DKD).
But the mechanism for such protection is not clear. Here, we report that in damaged proximal …
But the mechanism for such protection is not clear. Here, we report that in damaged proximal …
[HTML][HTML] Ketolysis drives CD8+ T cell effector function through effects on histone acetylation
KM Luda, J Longo, SM Kitchen-Goosen, LR Duimstra… - Immunity, 2023 - cell.com
Environmental nutrient availability influences T cell metabolism, impacting T cell function
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β …
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β …
The liver as an endocrine organ—linking NAFLD and insulin resistance
MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics
P Puchalska, PA Crawford - Cell metabolism, 2017 - cell.com
Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …
Cardiovascular effects of treatment with the ketone body 3-hydroxybutyrate in chronic heart failure patients
Background: Myocardial utilization of 3-hydroxybutyrate (3-OHB) is increased in patients
with heart failure and reduced ejection fraction (HFrEF). However, the cardiovascular effects …
with heart failure and reduced ejection fraction (HFrEF). However, the cardiovascular effects …
Metabolic flexibility as an adaptation to energy resources and requirements in health and disease
RL Smith, MR Soeters, RCI Wüst… - Endocrine …, 2018 - academic.oup.com
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …