Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

FLASH radiotherapy is a novel technique that has been shown in numerous preclinical in
vivo studies to have the potential to be the next important improvement in cancer treatment …

Radiation therapy for head and neck cancers causes salivary gland dysfunction leading to
permanent xerostomia. Limited progress in the discovery of new therapeutic strategies is …

We recently developed a salivary gland tissue mimetic (SGm), comprised of salivary gland
cells encapsulated in matrix metalloproteinase (MMP)–degradable poly (ethylene glycol) …

Purpose Radiation therapy for head and neck cancer frequently leads to salivary gland
damage and subsequent xerostomia. The radiation response of the parotid glands of rats …

Salivary gland damage caused by ionizing radiation (IR) severely affects the patient quality
of life and influences the efficacy of radiotherapy. Most current treatment modalities are …

Oral organoids are complex 3-dimensional structures that develop from stem cells or organ-
specific progenitors through a process of self-organization and re-create architectures and …

The majority of cancer patients will be treated with radiotherapy, either alone or together with
chemotherapy and/or surgery. Optimising the balance between tumour control and the …

Adult stem cells are responsible for homoeostasis and regeneration of epithelial tissues.
Stem cell function is regulated by both cell autonomous mechanisms as well as the niche …

Human salivary gland organoids have opened tremendous possibilities for regenerative
medicine in patients undergoing radiotherapy for the treatment of head and neck cancer …