Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

In addition to their role in glucose and lipid metabolism, adipocytes respond differentially to
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …

Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …

Obesity is associated with many adverse health effects, such as an increased
cardiometabolic risk. Despite higher adiposity for a given BMI, premenopausal women are at …

Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Obesity is an epidemic disease characterized by chronic low-grade inflammation associated
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …