The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

Parallel library synthesis is an important tool for drug discovery because it enables the
synthesis of closely related analogues in parallel via robust and general synthetic …

Chiral dialkyl carbinamines are important in fields such as organic chemistry,
pharmaceutical chemistry, and biochemistry, serving for example as bioactive molecules …

Hydrozirconation of various C= X functionalities with Schwartz's reagent is a powerful
method for preparing functionalized organic molecules, for instance aldehydes, amines, and …

Addition of the in situ generated Schwartz reagent to widely available isocyanates
constitutes a chemoselective, high-yielding, and versatile approach to the synthesis of …

Organic isocyanates are versatile intermediates that provide access to a wide range of
functionalities. In this work, we have developed the first synthetic method for preparing …

Isocyanates play a crucial role as key building blocks in the production of thermoplastic
foams, elastomers, adhesives, agrochemicals, and pharmaceuticals. These compounds are …

Hydroboration of isocyanates with HBPin was demonstrated using both catalytic and catalyst-
free approaches. In arene solvents, the reactions employed the commercially available and …

We report a facile, microwave-accelerated, one-pot tandem synthesis of unsymmetrical
ureas via a Curtius rearrangement. In this method, one-pot microwave irradiation of …

A protocol for the synthesis of unsymmetrical ureas substituted by pyridyl/quinolinyl moiety
has been developed. This method concluded in metal‐and base‐free reamination of N, N …