The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

The field of prebiotic chemistry has been dedicated over decades to finding abiotic routes
towards the molecular components of life. There is nowadays a handful of prebiotically …

The binding pockets of extant enzymes feature precise positioning of amino acid residues
that facilitate multiple complex transformations exploiting covalent and non-covalent …

In the early Earth, rudimentary enzymes must have utilized the available light energy source
to modulate protometabolic processes. Herein, we report the light-responsive C–C bond …

Living organisms are replete with rhythmic and oscillatory behavior at all levels, to the extent
that oscillations have been termed as a defining attribute of life. Recent studies of synthetic …

Biocatalytic reaction networks integrate complex cascade transformations via spatial
localization of multiple enzymes confined within the cellular milieu. Inspired by nature's …

The bottom-up synthesis of artificial, life-like systems promises to enable the study of
emergent properties distinctive to life. Here, we report protocell systems generated from …

The combination of covalent and non‐covalent synthesis is omnipresent in nature and
potentially enables access to new materials. Yet, the fundamental principles that govern …

The attainment of spatiotemporally inhomogeneous chemical and physical properties within
a system is gaining attention across disciplines due to the resemblance to environmental …

Transient self‐assembling systems often suffer from accumulation of chemical wastes that
interfere with the formation of pristine self‐assembled products in subsequent cycles …