Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …

The current era of COVID-19 is characterized by emerging variants of concern, waning
vaccine-and natural infection-induced immunity, debate over the timing and necessity of …

HIV viral reservoirs are established very early during infection. Resident memory T cells
(TRM) are present in tissues such as the lower female genital tract, but the contribution of …

Multiple drug discovery initiatives for tuberculosis are currently ongoing to identify and
develop new potent drugs with novel targets in order to shorten treatment duration. One of …

There is urgent need for new drug regimens that more rapidly cure tuberculosis (TB).
Existing TB drugs and regimens vary in treatment-shortening activity, but the molecular basis …

Comprehensive and spatially mapped molecular atlases of organs at a cellular level are a
critical resource to gain insights into pathogenic mechanisms and personalized therapies for …

During chronic human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV)
infection prior to AIDS progression, the vast majority of viral replication is concentrated within …

Background. HIV-positive patients had been successfully transplanted for the last 15 y and
the donor pool had successfully been expanded to also include HIV-positive donors …

The number of FDA-approved protein drugs (biologics), such as antibodies, antibody–drug
conjugates, hormones, and enzymes, continues to grow at a rapid rate; most of these drugs …

Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth
factor (NGF) have been demonstrated for their potential as a neuroregenerative treatment of …