Abstract Iron deficiency anemia affects> 1.2 billions individuals worldwide, and iron
deficiency in the absence of anemia is even more frequent. Total-body (absolute) iron …

Risk of disease is multifactorial and can be shaped by socio-economic, demographic,
cultural, environmental and genetic factors. Our understanding of the genetic determinants …

(CVD) in individuals with type 1 diabetes mellitus (T1DM), the pathophysiology underlying
the relationship between cardiovascular events, CVD risk factors, and T1DM is not well …

Genome-wide association studies have identified many noncoding variants associated with
common diseases and traits. We show that these variants are concentrated in regulatory …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

Chromatin profiling has emerged as a powerful means of genome annotation and detection
of regulatory activity. The approach is especially well suited to the characterization of non …

US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …

Genome-wide association studies (GWAS) have identified many risk loci for complex
diseases, but effect sizes are typically small and information on the underlying biological …

The remarkable phenotypic diversity of β thalassemia that range from severe anemia and
transfusion-dependency, to a clinically asymptomatic state exemplifies how a spectrum of …

By impairing both function and survival, the severe reduction in oxygen availability
associated with high-altitude environments is likely to act as an agent of natural selection …