Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …

Because of the limited tropism of HIV, in vivo modeling of this virus has been almost
exclusively limited to other lentiviruses such as SIV that reproduce many important …

No known therapies can prevent anaphylaxis. Bruton's tyrosine kinase (BTK) is an enzyme
thought to be essential for high-affinity IgE receptor (FcεRI) signaling in human cells. We …

Background Metastatic breast cancer (MBC) is incurable, with a 5-year survival rate of 28%.
In the USA, more than 42,000 patients die from MBC every year. The most common type of …

The hematopoietic humanized mouse (hu-mouse) model is a powerful resource to study and
manipulate the human immune system. However, a major and recurrent issue with this …

Autologous hematopoietic stem cell transplantation using genome-edited cells can become
a definitive therapy for hematological and non-hematological disorders with neurological …

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal bone-marrow
diseases with ineffective hematopoiesis resulting in cytopenias and morphologic dysplasia …

With the discovery of antiretroviral therapy, HIV-1 infection has transitioned into a
manageable but chronic illness, which requires lifelong treatment. Nevertheless, complete …

Genetically engineered pigs are a promising source for islet cell transplantation in type 1
diabetes, but the strong human anti-pig immune response prevents its successful clinical …

Animal experimentation has been integral to drug discovery and development and safety
assessment for many years, since it provides insights into the mechanisms of drug efficacy …