Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …

Despite massive investments in drug research and development, the significant decline in
the number of new drugs approved or translated to clinical use raises the question, whether …

Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …

Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show
that CAFs exert a physical force on cancer cells that enables their collective invasion. Force …

Cancer-associated fibroblasts (CAFs) are key actors in modulating the progression of many
solid tumors, such as breast cancer (BC). Herein, we identify an integrin α11/PDGFRβ …

In cancer, both histopathologic images and genomic signatures are used for diagnosis,
prognosis, and subtyping. However, combining histopathologic images with genomic data …

Histologically normal tissue adjacent to the tumor can provide insight of the
microenvironmental alterations surrounding the cancerous lesion and affecting the …

Brain tumors can be viewed as multicellular 'ecosystems' with increasingly recognized
cellular complexity and systemic impact. While the emerging diversity of malignant disease …

Analysis of gene expression data is widely used in transcriptomic studies to understand
functions of molecules inside a cell and interactions among molecules. Differential co …

Background There is a need to improve prediction of response to chemotherapy in breast
cancer in order to improve clinical management and this may be achieved by harnessing …