Emerging digital PCR technology in precision medicine

L Zhang, R Parvin, Q Fan, F Ye - Biosensors and Bioelectronics, 2022 - Elsevier
Digital PCR (dPCR) is built on partitioning reagent to the extent that single template
molecules are amplified and visualized individually, whereby offers higher precision and …

[HTML][HTML] Current and emerging techniques for antibiotic susceptibility tests

K Syal, M Mo, H Yu, R Iriya, W Jing, S Guodong… - Theranostics, 2017 - ncbi.nlm.nih.gov
Infectious diseases caused by bacterial pathogens are a worldwide burden. Serious
bacterial infection-related complications, such as sepsis, affect over a million people every …

Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging

Ö Baltekin, A Boucharin, E Tano… - Proceedings of the …, 2017 - National Acad Sciences
The emergence and spread of antibiotic-resistant bacteria are aggravated by incorrect
prescription and use of antibiotics. A core problem is that there is no sufficiently fast …

Rapid pathogen-specific phenotypic antibiotic susceptibility testing using digital LAMP quantification in clinical samples

NG Schoepp, TS Schlappi, MS Curtis… - Science translational …, 2017 - science.org
Rapid antimicrobial susceptibility testing (AST) is urgently needed for informing treatment
decisions and preventing the spread of antimicrobial resistance resulting from the misuse …

Activated alkyne-enabled turn-on click bioconjugation with cascade signal amplification for ultrafast and high-throughput antibiotic screening

S Lv, C Wang, K Xue, J Wang, M Xiao… - Proceedings of the …, 2023 - National Acad Sciences
Antimicrobial susceptibility testing plays a pivotal role in the discovery of new antibiotics.
However, the development of simple, sensitive, and rapid assessment approaches remains …

Rapid antibiotic susceptibility testing of pathogenic bacteria using heavy-water-labeled single-cell Raman spectroscopy in clinical samples

K Yang, HZ Li, X Zhu, JQ Su, B Ren, YG Zhu… - Analytical …, 2019 - ACS Publications
Speeding up antibiotic susceptibility testing (AST) is urgently needed in clincial settings to
guide fast and tailored antibiotic prescription before treatment. It remains a big challenge to …

Rapid Determination of Antimicrobial Susceptibility by Stimulated Raman Scattering Imaging of D2O Metabolic Incorporation in a Single Bacterium

M Zhang, W Hong, NS Abutaleb, J Li… - Advanced …, 2020 - Wiley Online Library
Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with
appropriate antibiotics and slowing down the emergence of antibiotic‐resistant bacteria …

Microfluidics for antibiotic susceptibility testing

W Postek, N Pacocha, P Garstecki - Lab on a Chip, 2022 - pubs.rsc.org
The rise of antibiotic resistance is a threat to global health. Rapid and comprehensive
analysis of infectious strains is critical to reducing the global use of antibiotics, as informed …

Diagnosis of bloodstream infections: an evolution of technologies towards accurate and rapid identification and antibiotic susceptibility testing

KC Tjandra, N Ram-Mohan, R Abe, MM Hashemi… - Antibiotics, 2022 - mdpi.com
Bloodstream infections (BSI) are a leading cause of death worldwide. The lack of timely and
reliable diagnostic practices is an ongoing issue for managing BSI. The current gold …

Recent advances in the race to design a rapid diagnostic test for antimicrobial resistance

H Leonard, R Colodner, S Halachmi, E Segal - ACS sensors, 2018 - ACS Publications
Even with advances in antibiotic therapies, bacterial infections persistently plague society
and have amounted to one of the most prevalent issues in healthcare today. Moreover, the …