Malaria is among one of the most devastating and deadliest parasitic disease in the world
claiming millions of lives every year around the globe. It is a mosquito-borne infectious …

Malaria continued to be a deadly situation for the people of tropical and subtropical
countries. Although there has been a marked reduction in new cases as well as mortality …

We report the discovery of marinoquinoline (3 H-pyrrolo [2, 3-c] quinoline) derivatives as
new chemotypes with antiplasmodial activity. We evaluated their inhibitory activities against …

Malaria still persists as one of the deadliest infectious disease having a huge morbidity and
mortality affecting the higher population of the world. Structure and ligand-based drug …

Approximately 619,000 malaria deaths were reported in 2021, and resistance to
recommended drugs, including artemisinin-combination therapies (ACTs), threatens malaria …

Plasmodium falciparum subtilisin-like serine protease 1 (PfSUB1) is essential for egress of
invasive merozoite forms of the parasite, rendering PfSUB1 an attractive antimalarial target …

Background Artemisinin-based combination therapy (ACT) is used as the first-line treatment
of uncomplicated malaria caused by the Plasmodium falciparum parasite and chloroquine …

We describe herein the design and synthesis of N-phenyl phthalimide derivatives with
inhibitory activities against Plasmodium falciparum (sensitive and resistant strains) in the low …

A series of ferrocenyl-containing γ-hydroxy-γ-lactam tetramates were prepared in 2–3 steps
through ring opening-ring closure (RORC) process of γ-ylidene-tetronate derivatives in the …

Neglected tropical diseases (NTDs) constitute a group of diseases that generally develop in
tropical or subtropical climatic conditions and are related to poverty. Within the spectrum of …