Alantolactone: a natural plant extract as a potential therapeutic agent for cancer

Y Cai, K Gao, B Peng, Z Xu, J Peng, J Li… - Frontiers in …, 2021 - frontiersin.org
Alantolactone (ALT) is a natural compound extracted from Chinese traditional medicine
Inula helenium L. with therapeutic potential in the treatment of various diseases. Recently, in …

Unraveling the therapeutic potential of carbamoyl phosphate synthetase 1 (CPS1) in human diseases

L Zhang, Y Zou, Y Lu, Z Li, F Gao - Bioorganic Chemistry, 2023 - Elsevier
CPS1, the rate-limiting enzyme that controls the first reaction of the urea cycle, is responsible
for converting toxic ammonia into non-toxic urea in mammals. While disruption of the …

Predicting lung adenocarcinoma prognosis, immune escape, and pharmacomic profile from arginine and proline-related genes

Z Wang, J Zhang, S Shi, H Ma, D Wang, C Zuo… - Scientific Reports, 2023 - nature.com
Lung adenocarcinoma (LUAD) is a highly heterogeneous disease that ranks first in
morbidity and mortality. Abnormal arginine metabolism is associated with inflammatory lung …

[HTML][HTML] Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis

L Mao, J Chen, X Lu, C Yang, Y Ding, M Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Metastasis is the major cause of high mortality in lung cancer. Exploring the underlying
mechanisms of metastasis thus holds promise for identifying new therapeutic strategies that …

A novel 14-gene signature for overall survival in lung adenocarcinoma based on the Bayesian hierarchical Cox proportional hazards model

N Sun, J Chu, W Hu, X Chen, N Yi, Y Shen - Scientific reports, 2022 - nature.com
There have been few investigations of cancer prognosis models based on Bayesian
hierarchical models. In this study, we used a novel Bayesian method to screen mRNAs and …

[HTML][HTML] Comprehensive analysis of the expression profile and clinical implications of regulator of chromosome condensation 2 in pan-cancers

X Li, K Kang, Y Peng, L Shen, L Shen, Y Zhou - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Abstract The Regulator of Chromosome Condensation 2 (RCC2) is an important gene that
regulates mitosis and cytoplasmic division in the cell cycle. Although there have been …

[HTML][HTML] The novel roles of virus infection-associated gene CDKN1A in chemoresistance and immune infiltration of glioblastoma

K Hu, J Li, G Wu, L Zhou, X Wang, Y Yan, Z Xu - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Chemoresistance is a common limitation for successful treatment of glioblastoma multiforme
(GBM). Recently, virus infections have been demonstrated to be associated with …

Biolabel-led research pattern positions the effects and mechanisms of Sophorae Tonkinensis radix et rhizome on lung diseases: a novel strategy for computer-aided …

S Zhang, Y He, X Li, Y Zhou - Computers in Biology and Medicine, 2021 - Elsevier
Previous studies have shown that Sophorae Tonkinensis radix et rhizome (ST) can be used
to treat some lung diseases. However, the therapeutic potentials, therapeutic advantages …

[HTML][HTML] A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and …

Q Chen, H Zhao, J Hu - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Accumulating evidence has demonstrated that chromatin regulators (CRs) regulate immune
cell infiltration and are correlated with prognoses of patients in some cancers. However, the …

A Regulatory Network Analysis of the Importance of USP15 in Breast Cancer Metastasis and Prognosis

J Ling, C Qin, T Li, B Wang, W Cai, L Ma… - Journal of …, 2022 - Wiley Online Library
Background. Ubiquitin‐specific protease15 (USP15), is the 16th identified protease in the
USP family and is a key protein in tumorigenesis. However, the predictive value and …