Evolution of adaptive optics retinal imaging
This review describes the progress that has been achieved since adaptive optics (AO) was
incorporated into the ophthalmoscope a quarter of a century ago, transforming our ability to …
incorporated into the ophthalmoscope a quarter of a century ago, transforming our ability to …
Promises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO)
Adaptive optics scanning light ophthalmoscopy (AOSLO) allows visualization of the living
human retina with exquisite single-cell resolution. This technology has improved our …
human retina with exquisite single-cell resolution. This technology has improved our …
Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo
In vivo fundus imaging offers non-invasive access to neuron structures and biochemical
processes in the retina. However, optical aberrations of the eye degrade the imaging …
processes in the retina. However, optical aberrations of the eye degrade the imaging …
In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury
Microglia respond to damage and microenvironmental changes within the central nervous
system by morphologically transforming and migrating to the lesion, but the real-time …
system by morphologically transforming and migrating to the lesion, but the real-time …
Separate lifetime signatures of macaque S cones, M/L cones, and rods observed with adaptive optics fluorescence lifetime ophthalmoscopy
In the retina, several molecules involved in metabolism, the visual cycle, and other roles
exhibit intrinsic fluorescence. The overall properties of retinal fluorescence depend on …
exhibit intrinsic fluorescence. The overall properties of retinal fluorescence depend on …
Imaging retinal activity in the living eye
JJ Hunter, WH Merigan… - Annual review of vision …, 2019 - annualreviews.org
Retinal function has long been studied with psychophysical methods in humans, whereas
detailed functional studies of vision have been conducted mostly in animals owing to the …
detailed functional studies of vision have been conducted mostly in animals owing to the …
Adaptive optics two-photon excited fluorescence lifetime imaging ophthalmoscopy of photoreceptors and retinal pigment epithelium in the living non-human primate …
S Walters, JA Feeks, KT Huynh… - Biomedical Optics Express, 2021 - opg.optica.org
Fluorescence lifetime imaging has demonstrated promise as a quantitative measure of cell
health. Adaptive optics two-photon excited fluorescence (TPEF) ophthalmoscopy enables …
health. Adaptive optics two-photon excited fluorescence (TPEF) ophthalmoscopy enables …
[HTML][HTML] Deep learning–assisted multiphoton microscopy to reduce light exposure and expedite imaging in tissues with high and low light sensitivity
Purpose: Two-photon excitation fluorescence (2PEF) reveals information about tissue
function. Concerns for phototoxicity demand lower light exposure during imaging. Reducing …
function. Concerns for phototoxicity demand lower light exposure during imaging. Reducing …
Visual system hyperexcitability and compromised V1 receptive field properties in early-stage retinitis pigmentosa in mice
Inherited retinal degenerative diseases are a prominent cause of blindness. Although
mutations causing death of photoreceptors are mostly known, the pathophysiology …
mutations causing death of photoreceptors are mostly known, the pathophysiology …
Boosting 2-photon vision with adaptive optics
HK Doyle, SR Herbeck, AE Boehm… - Journal of …, 2023 - jov.arvojournals.org
The 2-photon effect in vision occurs when two photons of the same wavelength are
absorbed by cone photopigment in the retina and create a visual sensation matching the …
absorbed by cone photopigment in the retina and create a visual sensation matching the …