Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

In response to different types and intensities of mechanical force, cells modulate their
physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …

In development, wound healing, and cancer metastasis, vertebrate cells move through 3D
interstitial matrix, responding to chemical and physical guidance cues. Protrusion at the cell …

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling
organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most …

Development, angiogenesis, wound healing, and metastasis all involve the movement of
cells in response to changes in the extracellular environment. To determine whether …

Abstract Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …

The introduction of the electron microscope to the study of the biological materials in the
second half of the last century has dramatically expanded our view and understanding of the …

Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling
regulators with numerous partners and whose activity is highly dependent on cellular …

Rho/ROCK signaling and caveolin-1 (Cav1) are implicated in tumor cell migration and
metastasis; however, the underlying molecular mechanisms remain poorly defined. Cav1 …