Measuring mechanical stress in living tissues

M Gómez-González, E Latorre, M Arroyo… - Nature Reviews …, 2020 - nature.com
Living tissues are active, multifunctional materials capable of generating, sensing,
withstanding and responding to mechanical stress. These capabilities enable tissues to …

[HTML][HTML] The excitable signal transduction networks: movers and shapers of eukaryotic cell migration

DS Pal, X Li, T Banerjee, Y Miao… - … International journal of …, 2019 - ncbi.nlm.nih.gov
In response to a variety of external cues, eukaryotic cells display varied migratory modes to
perform their physiological functions during development and in the adult. Aberrations in cell …

Three-dimensional balance of cortical tension and axial contractility enables fast amoeboid migration

B Álvarez-González, R Meili, E Bastounis, RA Firtel… - Biophysical journal, 2015 - cell.com
Fast amoeboid migration requires cells to apply mechanical forces on their surroundings via
transient adhesions. However, the role these forces play in controlling cell migration speed …

Cancer Metastasis‐on‐a‐Chip for Modeling Metastatic Cascade and Drug Screening

A Brooks, Y Zhang, J Chen… - Advanced Healthcare …, 2024 - Wiley Online Library
Microfluidic chips are valuable tools for studying intricate cellular and cell–microenvironment
interactions. Traditional in vitro cancer models lack accuracy in mimicking the complexities …

Coupling traction force patterns and actomyosin wave dynamics reveals mechanics of cell motion

E Ghabache, Y Cao, Y Miao, A Groisman… - Molecular systems …, 2021 - embopress.org
Motile cells can use and switch between different modes of migration. Here, we use traction
force microscopy and fluorescent labeling of actin and myosin to quantify and correlate …

Self-organized mechano-chemical dynamics in amoeboid locomotion of Physarum fragments

S Zhang, RD Guy, JC Lasheras… - Journal of physics D …, 2017 - iopscience.iop.org
The aim of this work is to quantify the spatio-temporal dynamics of flow-driven amoeboid
locomotion in small (∼ 100 μm) fragments of the true slime mold Physarum polycephalum …

Two-layer elastographic 3-D traction force microscopy

B Álvarez-González, S Zhang, M Gómez-González… - Scientific Reports, 2017 - nature.com
Cellular traction force microscopy (TFM) requires knowledge of the mechanical properties of
the substratum where the cells adhere to calculate cell-generated forces from …

Dendritic cell force-migration coupling on aligned fiber networks

C Hernandez-Padilla, B Joosten, A Franco, A Cambi… - Biophysical …, 2024 - cell.com
Dendritic cells (DCs) are antigen-presenting cells that reside in peripheral tissues and are
responsible for initiating adaptive immune responses. As gatekeepers of the immune …

Formation of multicellular colonies by choanoflagellates increases susceptibility to capture by amoeboid predators

NE Chin, TC Wu, JM O'Toole, K Xu… - Journal of Eukaryotic …, 2023 - Wiley Online Library
Many heterotrophic microbial eukaryotes are size‐selective feeders. Some microorganisms
increase their size by forming multicellular colonies. We used choanoflagellates …

Traditional Plant-Derived Compounds Inhibit Cell Migration and Induce Novel Cytoskeletal Effects in Glioblastoma Cells

E Thompson, S Prior, A Brüning-Richardson - Journal of Xenobiotics, 2024 - mdpi.com
Glioblastomas (GBMs) are aggressive and invasive cancers of the brain, associated with
high rates of tumour recurrence and poor patient outcomes despite initial treatment …