Glutamatergic systems in neuropathic pain and emerging non-opioid therapies

R Temmermand, JE Barrett, ACK Fontana - Pharmacological research, 2022 - Elsevier
Neuropathic pain, a disease of the somatosensory nervous system, afflicts many individuals
and adequate management with current pharmacotherapies remains elusive. The …

[HTML][HTML] β-Caryophyllene, a CB2-receptor-selective phytocannabinoid, suppresses mechanical allodynia in a mouse model of antiretroviral-induced neuropathic pain

E Aly, MA Khajah, W Masocha - Molecules, 2019 - mdpi.com
Neuropathic pain associated with nucleoside reverse transcriptase inhibitors (NRTIs),
therapeutic agents for human immunodeficiency virus (HIV), responds poorly to available …

Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects

MG Rahbardar, B Amin, S Mehri, SJ Mirnajafi-Zadeh… - Phytomedicine, 2018 - Elsevier
Background We aimed to investigate the potential prophylactic and curative effects of
rosmarinic acid, one of the main constituents of rosemary, on the neuropathic pain induced …

Intensive locomotor training provides sustained alleviation of chronic spinal cord injury-associated neuropathic pain: a two-year pre-clinical study

EA Dugan, B Schachner, S Jergova… - Journal of …, 2021 - liebertpub.com
Neuropathic pain often accompanies the functional deficits associated with spinal cord injury
(SCI) and further reduces a patient's quality of life. Clinical and pre-clinical research is …

[HTML][HTML] CX3CR1-targeted PLGA nanoparticles reduce microglia activation and pain behavior in rats with spinal nerve ligation

C Noh, HJ Shin, S Lee, SI Kim, YH Kim… - International Journal of …, 2020 - mdpi.com
Activation of CX3CR1 in microglia plays an important role in the development of neuropathic
pain. Here, we investigated whether neuropathic pain could be attenuated in spinal nerve …

Beneficial effects of fish oil enriched in omega-3 fatty acids on the development and maintenance of neuropathic pain

SR Unda, EA Villegas, ME Toledo… - Journal of Pharmacy …, 2020 - academic.oup.com
Objective The aim of this work was to assess the preventive effect of an eicosapentaenoic
acid/docosahexaenoic acid-concentrate fish oil on neuropathic pain development and …

Foxp3 plasmid-encapsulated PLGA nanoparticles attenuate pain behavior in rats with spinal nerve ligation

J Shin, Y Yin, DK Kim, SY Lee, W Lee, JW Kang… - … , Biology and Medicine, 2019 - Elsevier
Microglia play a critical role in neuropathic pain. Since upregulated Foxp3 in microglia
enhances tissue repair by resolving neuroinflammation in excitotoxin-induced neuronal …

[HTML][HTML] An electroencephalography bioassay for preclinical testing of analgesic efficacy

S Koyama, BW LeBlanc, KA Smith, C Roach, J Levitt… - Scientific reports, 2018 - nature.com
We present a multimodal method combining quantitative electroencephalography (EEG),
behavior and pharmacology for pre-clinical screening of analgesic efficacy in vivo. The …

[HTML][HTML] Indomethacin plus minocycline coadministration relieves chemotherapy and antiretroviral drug-induced neuropathic pain in a cannabinoid receptors …

W Masocha, A Thomas - Journal of Pharmacological Sciences, 2019 - Elsevier
Neuropathic pain sometimes occurs during chemotherapy with paclitaxel or HIV/AIDS
antiretroviral therapy with nucleoside reverse transcriptase inhibitors (NRTIs). We previously …

Effect of Umbelliprenin on antinociceptive activity of morphine in a rat model of neuropathic pain induced by chronic constriction injury of the sciatic nerve

S Nazemi, F Jafari, B Amin, O Gholami… - The Natural Products …, 2021 - ingentaconnect.com
Objective: Although morphine is among the first-line medicines for the treatment of
neuropathic pain, evidence has shown that the morphine efficacy gradually decreases and …