Topoisomerases are ubiquitous enzymes involved in maintaining genomic stability of the
cell by regulating the over-or underwinding of DNA strands. Besides their customary …

Type II topoisomerases are essential enzymes that regulate DNA under-and overwinding
and remove knots and tangles from the genetic material. In order to carry out their critical …

Although quinolones are the most commonly prescribed antibacterials, their use is
threatened by an increasing prevalence of resistance. The most common causes of …

Bacillus anthracis, the causative agent of anthrax, is considered a serious threat as a
bioweapon. The drugs most commonly used to treat anthrax are quinolones, which act by …

Phytochemicals are a rich source of anticancer drugs and chemopreventive agents. Several
of these chemicals appear to exert at least some of their effects through interactions with …

Significance: Iron and topoisomerases are abundant and essential cellular components. Iron
is required for several key processes such as DNA synthesis, mitochondrial electron …

Fluoroquinolones are one of the most widely prescribed classes of broad-spectrum
antibacterials currently in clinical use. These drugs kill bacteria by increasing DNA strand …

Organophosphorus Chemistry provides a comprehensive annual review of the literature.
Coverage includes phosphines and their chalcogenides, phosphonium salts, low …

Combined computational–experimental analyses explain and quantify the spermine-
vectorized F14512's boosted potency as a topoII poison. We found that an optimized …

Topoisomerases are critical cellular enzymes involved in the regulation of DNA topology.
These enzymes generate transient single-(type I) and double-strand (type II) DNA breaks in …