Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …

Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

As a key component of the inflammasome, NLRP3 is a critical intracellular danger sensor
emerging as an important clinical target in inflammatory diseases. However, little is known …

Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new
treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule …

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb
Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains …

Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form
inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D …

Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar
to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The …

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of
human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome …