Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents

A Najmi, SA Javed, M Al Bratty, HA Alhazmi - Molecules, 2022 - mdpi.com
Natural products represents an important source of new lead compounds in drug discovery
research. Several drugs currently used as therapeutic agents have been developed from …

Review on natural products databases: where to find data in 2020

M Sorokina, C Steinbeck - Journal of cheminformatics, 2020 - Springer
Natural products (NPs) have been the centre of attention of the scientific community in the
last decencies and the interest around them continues to grow incessantly. As a …

Natural product drug discovery in the artificial intelligence era

FI Saldívar-González, VD Aldas-Bulos… - Chemical …, 2022 - pubs.rsc.org
Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …

Natural product-based nanoformulations for cancer therapy: Opportunities and challenges

D Kashyap, HS Tuli, MB Yerer, A Sharma, K Sak… - Seminars in cancer …, 2021 - Elsevier
Application of natural product-based nanoformulations for the treatment of different human
diseases, such as cancer, is an emerging field. The conventional cancer therapeutic …

Counting on natural products for drug design

T Rodrigues, D Reker, P Schneider, G Schneider - Nature chemistry, 2016 - nature.com
Natural products and their molecular frameworks have a long tradition as valuable starting
points for medicinal chemistry and drug discovery. Recently, there has been a revitalization …

The re-emergence of natural products for drug discovery in the genomics era

AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

Unraveling plant natural chemical diversity for drug discovery purposes

E Lautié, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …

Natural products as a source for novel antibiotics

MG Moloney - Trends in pharmacological sciences, 2016 - cell.com
Natural products have historically been of crucial importance in the identification and
development of antibacterial agents. Interest in these systems has waned in recent years …

Natural products in drug discovery

AL Harvey - Drug discovery today, 2008 - Elsevier
Natural products have been the single most productive source of leads for the development
of drugs. Over a 100 new products are in clinical development, particularly as anti-cancer …

Natural products in crop protection

FE Dayan, CL Cantrell, SO Duke - Bioorganic & medicinal chemistry, 2009 - Elsevier
The tremendous increase in crop yields associated with the 'green'revolution has been
possible in part by the discovery and utilization of chemicals for pest control. However …