Cancer thrives in a complex environment where interactions between cellular and acellular
components, surrounding the tumor, play a crucial role in disease development and …

Abstract Two-dimensional (2D) cultures do not fully reflect the human organs' physiology
and the real effectiveness of the used therapy. Therefore, three-dimensional (3D) models …

High-fidelity in vitro tumor models are important for preclinical drug discovery processes.
Currently, the most commonly used model for in vitro drug testing remains the two …

Despite the advantages of microfluidic system in drug screening, vascular systems
responsible for the transport of drugs and nutrients have been hardly considered in the …

Emerging microfluidic disease models have amply demonstrated their value in many fields
of cancer research. These in vitro technologies recapitulate key aspects of metastatic …

The vasculature plays a critical role in cancer progression and metastasis, representing a
pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on …

Patient‐derived microphysiological systems (P‐MPS) have emerged as powerful tools in
precision medicine that provide valuable insight into individual patient characteristics. This …

Recent advances in tumor microenvironment (TME) modeling as well as its applications to
cancer therapy has brought various dramatical changes in multiple malignancies …

Cholangiocarcinoma (CCA) is a type of liver cancer with an aggressive phenotype and
dismal outcome in patients. The metastasis of CCA cancer cells to distant organs, commonly …

Diabetes mellitus (DM) has substantial global implications and contributes to vascular
inflammation and the onset of atherosclerotic cardiovascular diseases. However, translating …