Inflammation is emerging as a critical mechanism underlying neurological disorders of
various etiologies, yet its role in altering brain function as a consequence of neuroinfectious …

Activation of microglia and expression of the inflammatory cytokine interleukin-1 (IL-1) in the
CNS have become almost synonymous with neuroinflammation. In numerous studies …

Over 50% of patients who survive neuroinvasive infection with West Nile virus (WNV) exhibit
chronic cognitive sequelae,. Although thousands of cases of WNV-mediated memory …

We have discovered that native, neuronal expression of alpha-synuclein (Asyn) inhibits viral
infection, injury, and disease in the central nervous system (CNS). Enveloped RNA viruses …

Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor
necrosis factor family mediate this process. They either assist persistent viral infection or …

Viruses are ubiquitous intracellular genetic parasites that heavily rely on the infected cell to
complete their replication life cycle. This dependency on the host machinery forces viruses …

Background Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese
encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents …

Neuroinvasive infections with mosquito-borne alphaviruses such as Western equine
encephalitis virus (WEEV) can cause post-encephalitic parkinsonism. To understand the …

Abstract Purpose of Review: Arbovirus (arthropod-borne virus) infections are increasingly
important causes of neurologic disease in the United States through both endemic …

West Nile virus (WNV) is an important emerging neurotropic virus, responsible for
increasingly severe encephalitis outbreaks in humans and horses worldwide. However, the …