▪ Abstract Pseudogenes have been defined as nonfunctional sequences of genomic DNA
originally derived from functional genes. It is therefore assumed that all pseudogene …

For a long time lipid peroxidation has only been considered a deleterious process leading to
disruption of biomembranes and thus, to cellular dysfunction. However, when restricted to a …

Abstract Glutathione peroxidase 4 (GP x4) is the only enzyme capable of reducing toxic lipid
hydroperoxides in biological membranes to the corresponding alcohols using glutathione as …

Background Selenium is an essential trace element in mammals due to its presence in
proteins in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing …

Phospholipid hydroperoxide glutathione peroxidase (GPx4) is an intracellular antioxidant
enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the …

Embryo development relies on the complex interplay of the basic cellular processes
including proliferation, differentiation and apoptotic cell death. Precise regulation of these …

Retroelements comprise a considerable fraction of eukaryotic genomes. Since their initial
discovery by Barbara McClintock in maize DNA, retroelements have been found in genomes …

Selenoproteins have been recognized as modulators of brain function and signaling.
Phospholipid hydroperoxide glutathione peroxidase (GPx4/PHGPx) is a unique member of …

Selective ubiquitination of proteins is directed by diverse families of ubiquitin-protein ligases
(or E3s) in plants. One important type uses Cullin-3 as a scaffold to assemble multisubunit …

The development of an embryo constitutes a complex choreography of regulatory events
that underlies precise temporal and spatial control. Throughout this process the embryo …