The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …

Tacrine is a drug used in the treatment of Alzheimer's disease as a cognitive enhancer and
inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has …

In the present study, a series of eleven novel 1, 3‐diaryltriazene‐substituted sulfathiazole
moieties (ST1–11) was synthesized by the reaction of diazonium salt of sulfathiazole with …

A series of Fe (II), Ni (II), and Pd (II) complexes were prepared with a novel Schiff base
ligand containing pyridine moiety. The prepared compounds were characterized using FT …

Medicinal plants have been used traditionally since ancient times as alternative medications
to treat various human diseases. In this work, we examined the chemical constituent …

Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …

A series of previously synthesized conjugates of tacrine and salicylamide was extended by
varying the structure of the salicylamide fragment and using salicylic aldehyde to synthesize …

Alzheimer's disease (AD) is a neurodegenerative disorder which is characterized by β-
amyloid (Aβ) aggregation, τ-hyperphosphorylation, and loss of cholinergic neurons. The …

Alzheimer's disease (AD) is a chronic neurodegenerative disease that 4 widespread in the
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …

The cyclin-dependent kinase 7 (CDK7) plays a crucial role in regulating the cell cycle and
RNA polymerase-based transcription. Overexpression of this kinase is linked with various …