Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of Plasmodium falciparum 5 …

GO Oduselu, R Afolabi, I Ademuwagun… - Frontiers in …, 2023 - frontiersin.org
Plasmodium falciparum (Pf) 5-aminolevulinic acid synthase (5-ALAS) is an essential
enzyme with high selectivity during liver stage development, signifying its potential as a …

Deep learning methods for 3D structural proteome and interactome modeling

D Lee, D Xiong, S Wierbowski, L Li, S Liang… - Current opinion in …, 2022 - Elsevier
Bolstered by recent methodological and hardware advances, deep learning has
increasingly been applied to biological problems and structural proteomics. Such …

Synthesis, in silico and in vitro antimicrobial efficacy of substituted arylidene-based quinazolin-4(3H)-one motifs

GO Oduselu, DV Aderohunmu, OO Ajani… - Frontiers in …, 2023 - frontiersin.org
Introduction: Quinazolin-4 (3 H)-one derivatives have attracted considerable attention in the
pharmacological profiling of therapeutic drug targets. The present article reveals the …

Computational Modeling of Proteins Implicated in Hearing Loss

MRN Tollefson - 2023 - search.proquest.com
Hearing loss is associated with over 128,500 missense variants spanning 219 genes, and
approximately 6,300 of those missense variants have been classified as disease causing …

[PDF][PDF] Structural Biology

M He, A Kang, MJ Taussig - 2022 - ncbi.nlm.nih.gov
Contents Page 1 Nucleic Acids Research Contents Volume 23 number 19 October 11, 1995
RNA Distinct requirements for primary sequence in the 5'- and 3'-part of a bulge in the hepatitis …