The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Abstract The Third International Conference on Controversies in Vitamin D was held in
Gubbio, Italy, September 10–13, 2019. The conference was held as a follow up to previous …

This is a narrative review of the evidence supporting vitamin D's anticancer actions. The first
section reviews the findings from ecological studies of cancer with respect to indices of solar …

The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1, 25 …

The β-catenin signaling pathway is deregulated in nearly all colon cancers.
Nonhypercalcemic vitamin D3 (1α, 25-dehydroxyvitamin D3) analogues are candidate drugs …

Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis.
Hundreds of genes with vitamin D receptor response elements directly or indirectly influence …

Colorectal cancer (CRC) is the neoplasia that is most frequently associated with vitamin D
deficiency in epidemiological and observational studies in terms of incidence and mortality …

Vitamin D deficiency is linked to a range of muscle disorders including myalgia, muscle
weakness, and falls. Humans with severe vitamin D deficiency and mice with transgenic …

About 50 million of the US adult population suffer from chronic pain. It is a complex disease
in its own right for which currently available analgesics have been deemed woefully …

A low vitamin D status and inadequate calcium intake are important risk factors for various
types of cancer. Ecological studies using solar UV-B exposure as an index of vitamin D3 …