Quantum Dot–Peptide–Fullerene Bioconjugates for Visualization of in Vitro and in Vivo Cellular Membrane Potential

OK Nag, MH Stewart, JR Deschamps, K Susumu… - ACS …, 2017 - ACS Publications
We report the development of a quantum dot (QD)–peptide–fullerene (C60) electron transfer
(ET)-based nanobioconjugate for the visualization of membrane potential in living cells. The …

Design and demonstration of an intracortical probe technology with tunable modulus

DM Simon, H Charkhkar, C St. John… - … Research Part A, 2017 - Wiley Online Library
Intracortical probe technology, consisting of arrays of microelectrodes, offers a means of
recording the bioelectrical activity from neural tissue. A major limitation of existing …

Improving the performance of poly (3, 4-ethylenedioxythiophene) for brain–machine interface applications

HS Mandal, GL Knaack, H Charkhkar, DG McHail… - Acta biomaterialia, 2014 - Elsevier
Abstract Conducting polymers, especially poly (3, 4-ethylenedioxythiophene)(PEDOT)
based materials, are important for developing highly sensitive and microscale neural …

Amyloid beta modulation of neuronal network activity in vitro

H Charkhkar, S Meyyappan, E Matveeva, JR Moll… - Brain research, 2015 - Elsevier
In vitro assays offer a means of screening potential therapeutics and accelerating the drug
development process. Here, we utilized neuronal cultures on planar microelectrode arrays …

Use of cortical neuronal networks for in vitro material biocompatibility testing

H Charkhkar, C Frewin, M Nezafati, GL Knaack… - Biosensors and …, 2014 - Elsevier
Neural interfaces aim to restore neurological function lost during disease or injury. Novel
implantable neural interfaces increasingly capitalize on novel materials to achieve …

Establishment of a human neuronal network assessment system by using a human neuron/astrocyte co-culture derived from fetal neural stem/progenitor cells

K Fukushima, Y Miura, K Sawada… - Journal of …, 2016 - journals.sagepub.com
Using human cell models mimicking the central nervous system (CNS) provides a better
understanding of the human CNS, and it is a key strategy to improve success rates in CNS …

A Framework for the Comparative Assessment of Neuronal Spike Sorting Algorithms towards More Accurate Off‐Line and On‐Line Microelectrode Arrays Data …

G Regalia, S Coelli, E Biffi, G Ferrigno… - Computational …, 2016 - Wiley Online Library
Neuronal spike sorting algorithms are designed to retrieve neuronal network activity on a
single‐cell level from extracellular multiunit recordings with Microelectrode Arrays (MEAs). In …

Amorphous silicon carbide for neural interface applications

GL Knaack, H Charkhkar, SF Cogan… - Silicon Carbide …, 2016 - Elsevier
Implantable neural interfaces offer promise as prosthetic devices that enable communication
and control of artificial limbs for individuals suffering from paralysis and amputation. While …

Novel disposable microelectrode array for cultured neuronal network recording exhibiting equivalent performance to commercially available arrays

H Charkhkar, DE Arreaga-Salas, T Tran… - Sensors and Actuators B …, 2016 - Elsevier
Microelectrode arrays (MEAs) enable non-invasive recording of supra-threshold signals, ie
action potentials or spikes, from a variety of cultured electrically active cells. While this label …

Time-dependent increase in network response to stimulation

F Hamilton, R Graham, L Luu, N Peixoto - PloS one, 2015 - journals.plos.org
In vitro neuronal cultures have become a popular method with which to probe network-level
neuronal dynamics and phenomena in controlled laboratory settings. One of the key …