Notch signaling is an evolutionarily conserved pathway that regulates important biological
processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation …

Many biological circuits comprise sets of protein variants that interact with one another in a
many-to-many, or promiscuous, fashion. These architectures can provide powerful …

Genetic changes causing brain size expansion in human evolution have remained elusive.
Notch signaling is essential for radial glia stem cell proliferation and is a determinant of …

Somatic stem/progenitor cells are active in embryonic tissues but quiescent in many adult
tissues. The detailed mechanisms that regulate active versus quiescent stem cell states are …

Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates.
We find that this process can be induced in mouse MG, after injury, by transgenic expression …

In contrast to mammals, the adult zebrafish brain shows neurogenic activity in a multitude of
niches present in almost all brain subdivisions. Irrespectively, constitutive neurogenesis in …

Exosomes, a key element of the central nervous system microenvironment, mediate
intercellular communication via horizontally transferring bioactive molecules. Emerging …

Neural stem cells (NSCs) in the adult mouse hippocampal dentate gyrus (DG) are mostly
quiescent, and only a few are in cell cycle at any point in time. DG NSCs become …

Although the role of NOTCH signaling has been extensively studied in health and disease,
many questions still remain unresolved. Being crucial for tissue homeostasis, NOTCH …

Somatic stem/progenitor cells actively proliferate and give rise to different types of mature
cells (active state) in embryonic tissues while they are mostly dormant (quiescent state) in …