Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …

The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …

Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …

Microglia are resident macrophages of the central nervous system and significantly
contribute to overall brain function by participating in phagocytosis during development …

In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …

Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules
and are consequently involved in disease progression. We have investigated the proteomic …

Cerebral vessels are composed of highly complex structures that facilitate blood perfusion
necessary for meeting the high energy demands of the brain. Their geometrical complexities …