SLC7A11/xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells
Breast cancer cells evade cell death by overexpressing SLC7A11, which functions by
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …
miR-142-3p simultaneously targets HMGA1, HMGA2, HMGB1, and HMGB3 and inhibits tumorigenic properties and in-vivo metastatic potential of human cervical …
Aims High-mobility group (HMG) proteins are oncogenic in different cancers, including
cervical cancer; silencing their individual expression using sh-RNAs, siRNAs, and miRNAs …
cervical cancer; silencing their individual expression using sh-RNAs, siRNAs, and miRNAs …
HMGB3 inhibition by miR-142-3p/sh-RNA modulates autophagy and induces apoptosis via ROS accumulation and mitochondrial dysfunction and reduces the …
Aims High mobility group box (HMGB) family proteins, HMGB1, HMGB2, HMGB3, and
HMGB4 are oncogenic. The oncogenic nature of HMGB1 is characterized by its association …
HMGB4 are oncogenic. The oncogenic nature of HMGB1 is characterized by its association …
PP2A methylesterase PME‐1 suppresses anoikis and is associated with therapy relapse of PTEN‐deficient prostate cancers
While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable,
metastatic progression of PCa remains an unmet clinical challenge. Resistance to anoikis, a …
metastatic progression of PCa remains an unmet clinical challenge. Resistance to anoikis, a …
A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance
H Al-Akhrass, JRW Conway, ASA Poulsen, I Paatero… - Oncogene, 2021 - nature.com
Current evidence indicates that resistance to the tyrosine kinase-type cell surface receptor
(HER2)-targeted therapies is frequently associated with HER3 and active signaling via …
(HER2)-targeted therapies is frequently associated with HER3 and active signaling via …
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation
P Pekkonen, S Alve, G Balistreri, S Gramolelli… - Elife, 2018 - elifesciences.org
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in
melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis …
melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis …
Unveiling tumor microenvironment interactions using zebrafish models
R Loveless, C Shay, Y Teng - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The tumor microenvironment (TME) is a rich and active arena that is strategically evolved
overtime by tumors to promote their survival and dissemination. Over the years, attention has …
overtime by tumors to promote their survival and dissemination. Over the years, attention has …
Non-POU Domain-Containing Octomer-Binding (NONO) protein expression and stability promotes the tumorigenicity and activation of Akt/MAPK/β-catenin pathways …
Breast cancer is one of the most common cancers with a high mortality rate, underscoring
the need to identify new therapeutic targets. Here we report that non-POU domain …
the need to identify new therapeutic targets. Here we report that non-POU domain …
Drug screening of primary patient derived tumor xenografts in zebrafish
MG Haney, LH Moore, JS Blackburn - JoVE (Journal of Visualized …, 2020 - jove.com
Patient derived xenograft models are critical in defining how different cancers respond to
drug treatment in an in vivo system. Mouse models are the standard in the field, but …
drug treatment in an in vivo system. Mouse models are the standard in the field, but …
Spatiotemporal imaging and pharmacokinetics of fluorescent compounds in zebrafish eleuthero-embryos after different routes of administration
M Guarin, R Faelens, A Giusti, N De Croze… - Scientific reports, 2021 - nature.com
Zebrafish (Danio rerio) is increasingly used to assess the pharmacological activity and
toxicity of compounds. The spatiotemporal distribution of seven fluorescent alkyne …
toxicity of compounds. The spatiotemporal distribution of seven fluorescent alkyne …