Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease

CS Marnell, A Bick, P Natarajan - Journal of molecular and cellular …, 2021 - Elsevier
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …

Clonal hematopoiesis: Mutation-specific adaptation to environmental change

MA Florez, BT Tran, TK Wathan, J DeGregori… - Cell Stem Cell, 2022 - cell.com
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

[HTML][HTML] Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

A Heyde, D Rohde, CS McAlpine, S Zhang, FF Hoyer… - Cell, 2021 - cell.com
Clonal hematopoiesis, a condition in which individual hematopoietic stem cell clones
generate a disproportionate fraction of blood leukocytes, correlates with higher risk for …

Clonal hematopoiesis, somatic mosaicism, and age-associated disease

MA Evans, K Walsh - Physiological Reviews, 2023 - journals.physiology.org
Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Germline risk of clonal haematopoiesis

AJ Silver, AG Bick, MR Savona - Nature Reviews Genetics, 2021 - nature.com
Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease

AAZ Dawoud, RD Gilbert, WJ Tapper, NCP Cross - Leukemia, 2022 - nature.com
We sought to determine the relationship between age-related clonal hematopoiesis (CH)
and chronic kidney disease (CKD). CH, defined as mosaic chromosome abnormalities …

Association of diet quality with prevalence of clonal hematopoiesis and adverse cardiovascular events

R Bhattacharya, SM Zekavat, MM Uddin… - JAMA …, 2021 - jamanetwork.com
Importance Clonal hematopoiesis of indeterminate potential (CHIP), the expansion of
somatic leukemogenic variations in hematopoietic stem cells, has been associated with …

Cardiovascular disease among persons living with HIV: new insights into pathogenesis and clinical manifestations in a global context

M Ntsekhe, JV Baker - Circulation, 2023 - Am Heart Assoc
Widespread use of contemporary antiretroviral therapy globally has transformed HIV
disease into a chronic illness associated with excess risk for disorders of the heart and …

Biological ageing with HIV infection: evaluating the geroscience hypothesis

M Montano, KK Oursler, K Xu, YV Sun… - The Lancet Healthy …, 2022 - thelancet.com
Although people with HIV are living longer, as they age they remain disproportionately
burdened with multimorbidity that is exacerbated in resource-poor settings. The geroscience …

Clonal hematopoiesis: from mechanisms to clinical intervention

T Köhnke, R Majeti - Cancer discovery, 2021 - AACR
Our knowledge of how clonal hematopoiesis relates to diverse health conditions has grown
vastly over the past years, touching upon many specialties beyond cancer medicine. Given …