The methyltransferase-like (METTL) family is a diverse group of methyltransferases that can
methylate nucleotides, proteins, and small molecules. Despite this diverse array of …

ABSTRACT N-terminal methylation of the α-amine group (Nα-methylation) is a post-
translational modification (PTM) that was discovered over 40 years ago. Although it is not the …

ABSTRACT N-terminal methylation (Nα-methylation) by the methyltransferase NRMT1 is an
important post-translational modification that regulates protein–DNA interactions …

N-terminal protein methylation (Nα-methylation) is a posttranslational modification that
influences numerous biological processes by regulating protein stability, protein–DNA …

During the development of the vertebrate nervous system, 50% of the nerve cells undergo
apoptosis shortly after formation. This process is important for sculpting tissue during …

In the United States, it is now estimated that 6.7 million people over the age of 65 are
afflicted by Alzheimer's disease (AD), over 1 million people are living with Parkinson's …

Venglustat is a known allosteric inhibitor for ceramide glycosyltransferase, investigated in
diseases caused by lysosomal dysfunction. Here, we identified venglustat as a potent …

Protein N-terminal methyltransferase 1 (NTMT1) recognizes a unique N-terminal XPK/R
motif (X represents any amino acid other than D/E) and transfers 1–3 methyl groups to the N …

N-terminal protein methylation (Nα-methylation) is a post-translational modification (PTM)
that influences a variety of biological processes by regulating protein stability, protein-DNA …

Cell cycle proteins play essential roles in regulating embryonic and adult neurogenesis in
the mammalian brain. A key example is the Retinoblastoma protein (Rb) whose loss disrupts …