The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …

Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …

Heart failure remains a significant cause of morbidity and mortality following myocardial
infarction. Cardiac remuscularization with transplantation of human pluripotent stem cell …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome
caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking …

Cardiac in silico clinical trials can virtually assess the safety and efficacy of therapies using
human-based modelling and simulation. These technologies can provide mechanistic …

We reviewed the anatomical characteristics of the conduction system in the ventricles of
human and ungulate hearts and then raised some questions to be answered by clinical and …

Abstract Purpose of Review Recent technological advances have led to an increased ability
to define the gene expression profile of the cardiac conduction system (CCS). Here, we …

The principal function of the ventricular conduction system is rapid electrical activation of the
ventricles. The aim of this study is to conduct a morphometric study to pinpoint the …

Using transparent specimens with a dual color injection, microscopy, and computer
tomography, this report shows that the right and left ventricular subendocardial Purkinje …

The reconstruction of the ventricular cardiac conduction system (CCS) from patient‐specific
data is a challenging problem. High‐resolution imaging techniques have allowed only the …