NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms
SK Beaver, N Mesa-Torres, AL Pey… - Biochimica et Biophysica …, 2019 - Elsevier
Abstract NAD (P) H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that
catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic …
catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic …
NAD (P) H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places
Abstract NAD (P) H quinone oxidoreductase 1 (NQO1) catalyses the two electron reduction
of quinones and a wide range of other organic compounds. Its physiological role is believed …
of quinones and a wide range of other organic compounds. Its physiological role is believed …
Structural dynamics at the active site of the cancer‐associated flavoenzyme NQO1 probed by chemical modification with PMSF
A Grieco, MA Ruiz‐Fresneda, A Gómez‐Mulas… - FEBS …, 2023 - Wiley Online Library
A large conformational heterogeneity of human NAD (P) H: quinone oxidoreductase 1
(NQO1), a flavoprotein associated with various human diseases, has been observed to …
(NQO1), a flavoprotein associated with various human diseases, has been observed to …
Combination of lapatinib and luteolin enhances the therapeutic efficacy of lapatinib on human breast cancer through the FOXO3a/NQO1 pathway
L Zhang, Q Liu, L Huang, F Yang, A Liu… - … and Biophysical Research …, 2020 - Elsevier
Breast cancer is a malignant disease and a great cause of morbidity and mortality in women.
The etiology of breast cancer is complex and closely related to people's living habits …
The etiology of breast cancer is complex and closely related to people's living habits …
Virtual screening for potential phytobioactives as therapeutic leads to inhibit NQO1 for selective anticancer therapy
B Shreevatsa, C Dharmashekara, VH Swamy… - Molecules, 2021 - mdpi.com
NAD (P) H: quinone acceptor oxidoreductase-1 (NQO1) is a ubiquitous flavin adenine
dinucleotide-dependent flavoprotein that promotes obligatory two-electron reductions of …
dinucleotide-dependent flavoprotein that promotes obligatory two-electron reductions of …
Negative cooperativity in NAD (P) H quinone oxidoreductase 1 (NQO1)
CF Megarity, H Abdel‐Aal Bettley, MC Caraher… - …, 2019 - Wiley Online Library
Abstract NAD (P) H quinone oxidoreductase‐1 (NQO1) is a homodimeric protein that acts as
a detoxifying enzyme or as a chaperone protein. Dicourmarol interacts with NQO1 at the …
a detoxifying enzyme or as a chaperone protein. Dicourmarol interacts with NQO1 at the …
Identification of the naphthoquinone derivative inhibitors binding site in heat shock protein 90: an induced-fit docking, molecular dynamics and 3D-QSAR study
C Godoy-Castillo, N Bravo-Acuña… - Journal of …, 2021 - Taylor & Francis
The combination of molecular modeling methods to identify the putative binding site of
inhibitors constitutes an important tool in drug discovery. In this work, we used these …
inhibitors constitutes an important tool in drug discovery. In this work, we used these …
A combined 3D-QSAR, pharmacophore modelling, and molecular docking study for plastoquinone analogues
M Çınar - Eastern Anatolian Journal of Science, 2022 - dergipark.org.tr
In this study, a set consisting of 39 compounds that are in the literature and carrying
Plastoquinone analogues was investigated. The 3D-QSAR study was performed using a …
Plastoquinone analogues was investigated. The 3D-QSAR study was performed using a …
Structural dynamics at the active site of the cancer‐associated flavoenzyme NQO1 probed by chemical modification with PMSF
MÁ Ruiz Fresneda - 2023 - digibug.ugr.es
A large conformational heterogeneity of human NAD (P) H: quinone oxidoreductase 1
(NQO1), a flavoprotein associated with various human diseases, has been observed to …
(NQO1), a flavoprotein associated with various human diseases, has been observed to …
Identification of novel NAD (P) H dehydrogenase [quinone] 1 antagonist using computational approaches
R Selvakumar, DA Krishnan… - Journal of …, 2020 - Taylor & Francis
Abstract NAD (P) H: quinone oxidoreductase 1 (NQO1) inhibitors are proved as promising
therapeutic agents against cancer. This study is to determine potent NAD (P) H-dependent …
therapeutic agents against cancer. This study is to determine potent NAD (P) H-dependent …