Induced pluripotent stem cells in disease modelling and drug discovery
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …
widespread enthusiasm for the development of new models of human disease, enhanced …
Modeling the process of human tumorigenesis
Modelling the genesis of human cancers is at a scientific turning point. Starting from primary
sources of normal human cells, it is now possible to reproducibly generate several types of …
sources of normal human cells, it is now possible to reproducibly generate several types of …
In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells
Fusion oncogenes (FOs) are common in many cancer types and are powerful drivers of
tumor development. Because their expression is exclusive to cancer cells and their …
tumor development. Because their expression is exclusive to cancer cells and their …
Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia
D Sánchez-Martínez, ML Baroni… - Blood, The Journal …, 2019 - ashpublications.org
Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and
no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen …
no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen …
Human AML-iPSCs reacquire leukemic properties after differentiation and model clonal variation of disease
Understanding the relative contributions of genetic and epigenetic abnormalities to acute
myeloid leukemia (AML) should assist integrated design of targeted therapies. In this study …
myeloid leukemia (AML) should assist integrated design of targeted therapies. In this study …
[HTML][HTML] Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
A Agraz-Doblas, C Bueno, R Bashford-Rogers… - …, 2019 - ncbi.nlm.nih.gov
B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …
miR-130b and miR-128a are essential lineage-specific codrivers of t (4; 11) MLL-AF4 acute leukemia
Abstract t (4; 11) MLL-AF4 acute leukemia is one of the most aggressive malignancies in the
infant and pediatric population, yet we have little information on the molecular mechanisms …
infant and pediatric population, yet we have little information on the molecular mechanisms …
Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy
Y Lang, Y Lyu, Y Tan, Z Hu - Frontiers in Immunology, 2023 - frontiersin.org
Hematological malignancy is a disease arisen by complicate reasons that seriously
endangers human health. The research on its pathogenesis and therapies depends on the …
endangers human health. The research on its pathogenesis and therapies depends on the …
Efficient recreation of t (11; 22) EWSR1-FLI1+ in human stem cells using CRISPR/Cas9
Efficient methodologies for recreating cancer-associated chromosome translocations are in
high demand as tools for investigating how such events initiate cancer. The CRISPR/Cas9 …
high demand as tools for investigating how such events initiate cancer. The CRISPR/Cas9 …
Patient-derived iPSCs faithfully represent the genetic diversity and cellular architecture of human acute myeloid leukemia
AG Kotini, S Carcamo, N Cruz-Rodriguez… - Blood cancer …, 2023 - AACR
The reprogramming of human acute myeloid leukemia (AML) cells into induced pluripotent
stem cell (iPSC) lines could provide new faithful genetic models of AML, but is currently …
stem cell (iPSC) lines could provide new faithful genetic models of AML, but is currently …