The roles of histone variants in fine-tuning chromatin organization and function
S Martire, LA Banaszynski - Nature reviews Molecular cell biology, 2020 - nature.com
Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …
post-translational modification and chromatin remodelling complexes, histone variants …
Zygotic genome activation during the maternal-to-zygotic transition
MT Lee, AR Bonneau, AJ Giraldez - Annual review of cell and …, 2014 - annualreviews.org
Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …
animals, maternal factors contributed by the egg cytoplasm initially control development …
Every amino acid matters: essential contributions of histone variants to mammalian development and disease
I Maze, KM Noh, AA Soshnev, CD Allis - Nature Reviews Genetics, 2014 - nature.com
Despite a conserved role for histones as general DNA packaging agents, it is now clear that
another key function of these proteins is to confer variations in chromatin structure to ensure …
another key function of these proteins is to confer variations in chromatin structure to ensure …
Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions
V Turinetto, C Giachino - Nucleic acids research, 2015 - academic.oup.com
In the last decade, many papers highlighted that the histone variant H2AX and its
phosphorylation on Ser 139 (γH2AX) cannot be simply considered a specific DNA double …
phosphorylation on Ser 139 (γH2AX) cannot be simply considered a specific DNA double …
Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo
An open chromatin architecture devoid of compact chromatin is thought to be associated
with pluripotency in embryonic stem cells. Establishing this distinct epigenetic state may also …
with pluripotency in embryonic stem cells. Establishing this distinct epigenetic state may also …
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency
A Gaspar-Maia, ZA Qadeer, D Hasson… - Nature …, 2013 - nature.com
The chromatin template imposes an epigenetic barrier during the process of somatic cell
reprogramming. Using fibroblasts derived from macroH2A double knockout (dKO) mice …
reprogramming. Using fibroblasts derived from macroH2A double knockout (dKO) mice …
[HTML][HTML] Chromatin modifications in the germinal vesicle (GV) of mammalian oocytes
R De La Fuente - Developmental biology, 2006 - Elsevier
The nucleus of eukaryotic cells is organized into functionally specialized compartments that
are essential for the control of gene expression, chromosome architecture and cellular …
are essential for the control of gene expression, chromosome architecture and cellular …
Sculpting the transcriptome during the oocyte-to-embryo transition in mouse
In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …
What does it take to make a developmentally competent mammalian egg?
M Zuccotti, V Merico, S Cecconi… - Human reproduction …, 2011 - academic.oup.com
BACKGROUND A limitation to our ability to distinguish between developmentally competent
and incompetent eggs is our still only partial knowledge of the critical features that are …
and incompetent eggs is our still only partial knowledge of the critical features that are …
Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo
VB Alarcon - Biology of reproduction, 2010 - academic.oup.com
In preimplantation mouse development, the first cell lineages to be established are the
trophectoderm (TE) and inner cell mass. TE possesses epithelial features, including apical …
trophectoderm (TE) and inner cell mass. TE possesses epithelial features, including apical …