The C3 glomerulopathies are a group of rare kidney diseases characterized by complement
dysregulation occurring in the fluid phase and in the glomerular microenvironment, which …

Complement activation has a role in the pathogenesis of IgA nephropathy, an autoimmune
disease mediated by pathogenic immune complexes consisting of galactose-deficient IgA1 …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

Dense deposit disease and glomerulonephritis with isolated C3 deposits are
glomerulopathies characterized by deposits of C3 within or along the glomerular basement …

This review discusses the causes, pathogenesis, and clinical management of
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …

Renal pathologists and nephrologists met on February 20, 2015 to establish an
etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aim …

Results The subjects included three patients with dense deposit disease (including one
patient with recurrent dense deposit disease in allograft) and three patients with C3 …

C3 glomerulonephritis (C3GN) is a recently described disorder that typically results from
abnormalities in the alternative pathway (AP) of complement. Here, we describe the clinical …

Monoclonal gammopathies are characterized by the overproduction of monoclonal Ig (MIg)
detectable in the serum or urine resulting from a clonal proliferation of plasma cells or B …

Several distinct pathological patterns of glomerular inflammation are associated with
abnormal regulation of the complement system, specifically, with dysregulation of the …