The growing field of immune metabolism has revealed promising indications for metabolic
targets to modulate anti-cancer immunity. Combination therapies involving metabolic …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …

Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor
microenvironment. The main feature of these cells is their potent immune suppressive …

Among the various immunological and non-immunological tumor-promoting activities of
myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a …

Immune cells play a key role in host defense against infection and cancer. Upon
encountering danger signals, these cells undergo activation leading to a modulation in their …

The generation of an inflammatory environment is favorable and often decisive for the
growth of both primary tumors and metastases. Tumor cells either express membrane …

Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share
origin and many morphological and phenotypic features. However, they have different …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

Myeloid-derived suppressor cells (MDSC) promote tumor growth by inhibiting T-cell
immunity and promoting malignant cell proliferation and migration. The therapeutic potential …

Metformin is a broadly prescribed drug for type 2 diabetes that exerts antitumor activity, yet
the mechanisms underlying this activity remain unclear. We show here that metformin …