Migraine as an allostatic reset triggered by unresolved interoceptive prediction errors
Until now, a satisfying account of the cause and purpose of migraine has remained elusive.
We explain migraine within the frameworks of allostasis (the situationally-flexible, forward …
We explain migraine within the frameworks of allostasis (the situationally-flexible, forward …
Diffuse noxious inhibitory controls and conditioned pain modulation: a shared neurobiology within the descending pain inhibitory system?
L Sirucek, RP Ganley, HU Zeilhofer, P Schweinhardt - Pain, 2023 - journals.lww.com
Descending pain inhibition is a key component of physiological and pathological pain
processing. 70 Various neurotransmitter systems underlie different descending pain …
processing. 70 Various neurotransmitter systems underlie different descending pain …
The effect of palmitoylethanolamide on pain intensity, central and peripheral sensitization, and pain modulation in healthy volunteers—a randomized, double-blinded …
K Lang-Illievich, C Klivinyi, G Rumpold-Seitlinger… - Nutrients, 2022 - mdpi.com
Palmitoylethanolamide (PEA) is marketed as a “dietary food for special medical purposes”.
Its broad-spectrum analgesic, anti-inflammatory, and neuroprotective effects make PEA an …
Its broad-spectrum analgesic, anti-inflammatory, and neuroprotective effects make PEA an …
Mechanisms and manifestations in musculoskeletal pain: from experimental to clinical pain settings
T Graven-Nielsen - Pain, 2022 - journals.lww.com
Musculoskeletal pain is an extensive societal challenge, due to the large population
affected, an increased expected life span, and the lack of efficient prevention and treatment …
affected, an increased expected life span, and the lack of efficient prevention and treatment …
Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice
Descending control of nociception (DCN; also known as conditioned pain modulation [CPM],
the behavioral correlate of diffuse noxious inhibitory controls) is the phenomenon whereby …
the behavioral correlate of diffuse noxious inhibitory controls) is the phenomenon whereby …
Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection
Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …
Involvement of propriospinal processes in conditioned pain modulation
Conditioned pain modulation (CPM) refers to the “pain inhibits pain” phenomenon in which
a spatially remote noxious stimulus (conditioning stimulus [CS]) may change the perceived …
a spatially remote noxious stimulus (conditioning stimulus [CS]) may change the perceived …
Designer Receptor Exclusively Activated by Designer Drug (DREADD)-Mediated Activation of the Periaqueductal Gray Restores Nociceptive Descending Inhibition …
KA Irvine, XY Shi, AR Ferguson, JD Clark - Journal of Neurotrauma, 2024 - liebertpub.com
Traumatic brain injury (TBI) patients frequently experience chronic pain that can enhance
their suffering and significantly impair rehabilitative efforts. Clinical studies suggest that …
their suffering and significantly impair rehabilitative efforts. Clinical studies suggest that …
[HTML][HTML] Diffuse noxious inhibitory controls in chronic joint inflammatory pain: study of the descending serotonergic modulation mediated through 5HT3 receptors
R Pereira-Silva, P Serrão, FL Neto, I Martins - Neurobiology of Pain, 2023 - Elsevier
The loss of diffuse noxious inhibitory controls (DNIC) is recognized as a predictor of chronic
pain. Mechanistically, DNIC produces analgesia by a heterotopically applied conditioning …
pain. Mechanistically, DNIC produces analgesia by a heterotopically applied conditioning …
Therapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disorders
M Branković, T Gmizić, M Dukić, M Zdravković… - Antioxidants, 2024 - mdpi.com
Palmitoylethanolamide (PEA) is an endocannabinoid-like bioactive lipid mediator belonging
to the family of N-acylethanolamines, most abundantly found in peanuts and egg yolk. When …
to the family of N-acylethanolamines, most abundantly found in peanuts and egg yolk. When …